Basicity of Amines And pKaH
Quantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
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5 Key Basicity Trends of Amines
5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreOrganometallics Are Strong Bases
Reactions of Grignard Reagents With Water, Carboxylic Acids, And Other Mildly Acidic Species Last post we talked about how to make certain organometallics, specifically Grignard
Read moreAlcohols Can Act As Acids Or Bases (And Why It Matters)
Alcohols: The Conjugate Acid Is A Better Leaving Group, and The Conjugate Base Is A Better Nucleophile In the last post we explored some of the properties and
Read moreAlcohols – Acidity and Basicity
Acid-Base Reactions Of Alcohols Alcohols are mild acids. Typical aliphatic (i.e. “alkyl”) alcohols such as ethanol, isopropanol, and t-butanol have a pKa of about 16-18, making
Read moreThe Conjugate Acid Is A Better Leaving Group
Adding Acid Increases Leaving Group Ability Sure, it’s one thing to recognize halogens (Cl, Br, and I) as having high leaving group ability, as well
Read moreAcid Base Reactions In Organic Chemistry
An Introduction to Acid Base Reactions In Organic Chemistry Now that we’ve described how to figure out where the electrons are in a molecule, the
Read moreThe Stronger The Acid, The Weaker The Conjugate Base
Basicity In Organic Chemistry: Some Basicity Trends Today we’ll look at a simple periodic basicity trend across the periodic table and extrapolate from it some
Read moreWalkthrough of Acid-Base Reactions (3) – Acidity Trends
Acidity Trends In Organic Molecules Here, we’ll review the key trends that affect acidity, which all have the common effect of stabilizing negative charge (or more broadly,
Read moreFive Key Factors That Influence Acidity
Five Key Factors That Affect Acidity Today we’ll talk about what’s behind the trends in acidity for different molecules and discuss the most important factors
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